Clinical and bacteriological evaluation of sisomicin in sixteen cases of severe bronchopulmonary infection
Identifieur interne : 002B50 ( Main/Exploration ); précédent : 002B49; suivant : 002B51Clinical and bacteriological evaluation of sisomicin in sixteen cases of severe bronchopulmonary infection
Auteurs : H. Duwoos [France] ; C. Guyonnaud [France] ; J. Nouveau [France] ; P. Carpentier [France] ; C. Abderhalden [France]Source :
- Infection [ 0300-8126 ] ; 1976-12-01.
Abstract
Summary: Sisomicin, an aminoglycoside antibiotic, was used as sole bactericidal therapy in sixteen cases of severe bronchopulmonary infection for an average of 11.5 days (range 7 to 14) with a dose of 3.5 mg/kg per day in three intramuscular injections. Fifteen of these hospitalized patients presented with chronic airway obstruction which resulted in lowered O2 saturation (SaO2-86.1%, range 74 to 93) and, in twelve patients, hypercapnia (PaCO2=55.7 torr, range 33–73). Two of these patients were under continuous assisted ventilation. Two patients had a lower lobe infiltrate and a lung abcess respectively. Proteus (n=3), Pseudomonas (n=9), K. pneumoniae (n=2), E.coli (n=1), Enterobacter (n=1), S. aureus (n=1) and D. pneumoniae (n=1) were the dominant organisms in the bronchial secretions isolated by Mulder's method; P. aeruginosa was associated with K. pneumoniae, P. rettgeri and E.coli respectively in three cases. In thirteen cases, either a clinical cure (n=2) or a definite improvement was observed (sputum volume and purulence, auscultatory signs, temperature). However, among these patients were three cases of superinfection/colonization and two cases of persistent organisms. In addition, in two of the three cases showing no improvement colonization occurred. The favorable results of this study appear to be due to vigorous antibiotic therapy combined with intensive adjunct therapy. No adverse local or systemic reactions clearly attributable to the drug were observed.
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DOI: 10.1007/BF01646987
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Fifteen of these hospitalized patients presented with chronic airway obstruction which resulted in lowered O2 saturation (SaO2-86.1%, range 74 to 93) and, in twelve patients, hypercapnia (PaCO2=55.7 torr, range 33–73). Two of these patients were under continuous assisted ventilation. Two patients had a lower lobe infiltrate and a lung abcess respectively. Proteus (n=3), Pseudomonas (n=9), K. pneumoniae (n=2), E.coli (n=1), Enterobacter (n=1), S. aureus (n=1) and D. pneumoniae (n=1) were the dominant organisms in the bronchial secretions isolated by Mulder's method; P. aeruginosa was associated with K. pneumoniae, P. rettgeri and E.coli respectively in three cases. In thirteen cases, either a clinical cure (n=2) or a definite improvement was observed (sputum volume and purulence, auscultatory signs, temperature). However, among these patients were three cases of superinfection/colonization and two cases of persistent organisms. In addition, in two of the three cases showing no improvement colonization occurred. The favorable results of this study appear to be due to vigorous antibiotic therapy combined with intensive adjunct therapy. No adverse local or systemic reactions clearly attributable to the drug were observed.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Haute-Normandie</li><li>Région Normandie</li></region><settlement><li>Le Havre</li></settlement></list><tree><country name="France"><region name="Région Normandie"><name sortKey="Duwoos, H" sort="Duwoos, H" uniqKey="Duwoos H" first="H." last="Duwoos">H. Duwoos</name></region><name sortKey="Abderhalden, C" sort="Abderhalden, C" uniqKey="Abderhalden C" first="C." last="Abderhalden">C. Abderhalden</name><name sortKey="Carpentier, P" sort="Carpentier, P" uniqKey="Carpentier P" first="P." last="Carpentier">P. Carpentier</name><name sortKey="Guyonnaud, C" sort="Guyonnaud, C" uniqKey="Guyonnaud C" first="C." last="Guyonnaud">C. Guyonnaud</name><name sortKey="Nouveau, J" sort="Nouveau, J" uniqKey="Nouveau J" first="J." last="Nouveau">J. Nouveau</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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